Inosine monophosphate overcomes the coexisting resistance of mcr-1 and bla_NDM-1 in Escherichia coli.

ABSTRACT:

Introduction

The rise of antibiotic-resistant bacteria, particularly those harboring mcr-1 and bla_NDM-1, threatens public health by reducing the efficacy of colistin and carbapenems. Recently, the co-spread of mcr-1 and bla_NDM-1 has been reported, and the emergence of dual-resistant Enterobacteriaceae severely exacerbates antimicrobial resistance.

Objectives

This study aims to investigate the impact of mcr-1 and bla_NDM-1 expression on metabolism in Escherichia coli and to identify potential antimicrobial agents capable of overcoming the resistance conferred by these genes.

Methods

We employed non-targeted metabolomics to profile the metabolic perturbations of E. coli strains harboring mcr-1 and bla_NDM-1. The bactericidal eff

SUBMITTER: Zhao L 

PROVIDER: S-EPMC12766178 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature