Deficit of neuronal EAAT2 impairs hippocampus CA3 neuron's activity and may induce depressive like behaviors.

ABSTRACT:

Introduction

Major depressive disorder (MDD) is a severe neuropsychiatric disease that is accompanied by hippocampal dysfunction. Currently, the complex neuronal types and molecules involved in the various hippocampal subfields in patients with depression remain unclear.

Objectives

We focused on the role of hippocampal excitatory amino acid transporter 2 (EAAT2) in chronic stress.

Methods

We studied two chronic stress models, the chronic unpredictable mild stress (CUMS) and the chronic social defeat stress (CSDS) models, and performed pharmacological inhibition, genetic manipulations to examine overexpression of neuron-specific solute carrier family 1 member 2 (SLC1A2), the gene encoding EAAT2, in the dorsal CA3 and conditional Slc1a2 knockout in CA3, whole-cell recor

SUBMITTER: Cheng K 

PROVIDER: S-EPMC12766208 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature