Blood metabolites mediate causal inference studies on the effect of gut microbiota on the risk of vascular calcification.

ABSTRACT:

Background

Emerging evidence indicates a notable connection between gut microbiota and Vascular Calcification (VC). Gut microbiota influences various disease processes through host metabolic pathways; however, the causative link between gut microbiota and VC, along with the potential mediating role of metabolites, is still not well understood.

Methods

We leveraged data from the largest Genome-Wide Association Studies (GWAS) concerning gut microbiota, blood metabolites, and VC. To explore the causal relationships among these variables, we conducted two-sample bidirectional Mendelian Randomization (MR) analyses. Furthermore, mediation analyses were conducted to determine if metabolites act as an intermediary in the impact of gut microbiota on VC. In addition, we recruited CKD

SUBMITTER: Huang A 

PROVIDER: S-EPMC12766209 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature