MG53 protects against septic cardiac dysfunction by ubiquitinating ATF2.

ABSTRACT:

Introduction

Septic cardiac dysfunction (SCD) is the most common complication of sepsis, which has become the primary cause of death in intensive care units. The muscle-specific protein mitsugumin-53 (MG53) has been identified to protect cell integrity as a "Molecular Band-Aid".

Objectives

The recombinant human MG53 (rhMG53) pretreatment has been reported to prevent cardiac function damage caused by cecal ligation and puncture (CLP). However, whether or not MG53 protects against SCD remains to be further clarified.

Methods

C57BL/6J mice were intraperitoneally injected with lipopolysaccharide (LPS) to generate the SCD model. MG53 was overexpressed by intravenously injected adeno-associated virus, and the rhMG53 was administrated intraperitoneally. The cardiac function

SUBMITTER: Tian M 

PROVIDER: S-EPMC12766226 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature