The LRP1-SHP2 pathway regulates TRPV1 sensitivity in the peripheral nervous system: Insights from amyloid beta 1-42 modulation.

ABSTRACT:

Introduction

Mature adults often exhibit higher pain thresholds than younger individuals. However, this phenomenon is poorly understood, especially with regards to peripheral nervous system signaling.

Objectives

We investigated the involvement of amyloid beta (Aβ) in regulating heat pain sensitivity within the dorsal root ganglion (DRG) during adult maturation.

Methods

We employed various in vivo and in vitro techniques to investigate the modulatory effect of Aβ_1-42. Heat pain sensitivity alteration was examined in spared nerve injury (SNI) models of young and mature adult Aβ_1-42-treated mice. Phosphorylation and receptor inhibition assays were performed to elucidate the molecular mechanisms involved in pathway interactions in vitro.

Results</

SUBMITTER: Hwang SM 

PROVIDER: S-EPMC12766229 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature