Gastrointestinal traits, common inflammatory disorders, gallstones, and biliary tract cancer: A network Mendelian randomization study.

ABSTRACT:

Introduction

Observational studies have shown that gallstone disease (GSD), cholecystitis, cholangitis, polyp of gallbladder, viral hepatitis, pancreatitis and gastrointestinal (GI) traits such as H. pylori infection, inflammatory bowel disease, and digestive ulcer are associated with the risk of biliary tract cancer (BTC). However, no study has explored their causal associations.

Objectives

To gain a more comprehensive understanding of the causal relationships between GI traits, inflammatory diseases of the digestive system, gallstones, and the development of BTC, further investigation into a comprehensive causal network is warranted.

Methods

Based on findings of our Meta-analysis, the present study proposed to investigate the causal role of GSD (26,122 recorded case

SUBMITTER: Bai Y 

PROVIDER: S-EPMC12766238 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature