The probiotic enhances donor microbiota stability and improves the efficacy of fecal microbiota transplantation for treating colitis.

ABSTRACT:

Introduction

The stability and metabolic functionality of donor microbiota are critical determinants of fecal microbiota transplantation (FMT) efficacy in inflammatory bowel disease (IBD). While probiotics show potential to enhance microbiota resilience, their role in optimizing donor microbiota for FMT remains underexplored.

Objectives

This study investigated whether pretreatment of donor microbiota with L. plantarum GR-4 could improve FMT outcomes in a DSS-induced colitis model by modulating microbial stability, metabolic activity, and host-microbiome interactions.

Methods

Donor mice received L. plantarum GR-4 for 3 weeks to generate modified FMT (MFMT). DSS-colitis mice were treated with MFMT, conventional FMT, or 5-aminosalicylic acid (5-ASA). Multi-omics analyses

SUBMITTER: Fan J 

PROVIDER: S-EPMC12766252 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature