Liraglutide Ameliorates Injury-Related Vascular Repair by Activating Autophagy Through Modulation of the PI3K-mTOR Signaling Pathway.

ABSTRACT: Chronic stress is a significant risk factor for postoperative restenosis and other cardiovascular diseases, as it can promote the intimal thickening of damaged vessels. Liraglutide is used primarily for the treatment of type 2 diabetes and obesity. Recently, the protective effects of liraglutide on the cardiovascular system have garnered widespread attention; however, its specific mechanism of action remains unknown. The aim of this study was to investigate the impact of liraglutide on chronic stress-induced thickening of the damaged vascular intima and to elucidate the underlying mechanism involved. A dual in vivo model of chronic stress and carotid intima injury was adopted to investigate the effects of chronic stress on vascular morphology, blood biochemistry, and the expression of auto

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC12766259 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature