Gnetumgams A and B: two new 2-phenylbenzofuran derivatives from the lianas of <i>Gnetum montanum</i> with xanthine oxidase inhibitory activity.

ABSTRACT: Gnetum montanum ("", Gnetaceae), traditionally employed in Vietnam for the treatment of rheumatism, chronic bronchitis, menstrual disorders, and as an antidote, was investigated for xanthine oxidase (XO) inhibitory constituents. Bioassay-guided fractionation led to the isolation of five 2-phenylbenzofurans, including two previously undescribed metabolites, gnetumgam A (1) and gnetumgam B (2), along with gnetifolin M (3), gnetifolin A (4), and gnetumelin B (5). Structures were unambiguously elucidated by comprehensive spectroscopic analyses (1D/2D NMR, HR-ESI-MS) and comparison with reference data. Among these, gnetumgam B (2) and gnetifolin M (3) exhibited notable XO inhibition (IC₅₀ = 111.7 and 113.1 µM, respectively), although less potent than the clinical agents allopu

SUBMITTER: Van Do TN 

PROVIDER: S-EPMC12766261 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature