Magnetic resonance T1ρ relaxation in patients with liver fibrosis: a systematic review and meta-analysis.

ABSTRACT:

Purpose

This study aimed to evaluate the diagnostic performance of T1ρ relaxation in distinguishing patients with liver fibrosis (LF) from those without.

Methods

A systematic review was conducted using PubMed, EMBASE, Cochrane, and Web of Science databases up to February 2025 to identify studies assessing T1ρ for LF diagnosis.

Results

Eleven studies involving 792 patients were included. T1ρ values were significantly higher in cirrhotic versus normal livers [weighted mean difference (WMD): 6.69, P < 0.001], and in fibrotic versus normal livers (WMD: 7.17, P = 0.006). Patients with Child-Pugh classes A, B, and C showed significantly higher T1ρ values compared with normal liver (P < 0.001). T1ρ values in LF stages F1-F3 were not significantly differe

SUBMITTER: Liu X 

PROVIDER: S-EPMC12766347 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature