Long-term risk factors of stoma construction after loose seton placement for Crohn disease-associated perianal fistulas.

ABSTRACT:

Purpose

To evaluate long-term outcomes and identify prognostic factors for stoma construction following loose seton placement in patients with Crohn disease (CD)-associated perianal fistulas.

Methods

This single-center, retrospective study included 136 patients who underwent initial loose seton placement for CD-associated perianal fistulas between 1999 and 2021, with at least 3 years of follow-up. Patient demographics, anorectal findings, and perioperative pharmacotherapy were assessed. Prognosis was defined as the cumulative incidence of stoma formation. Independent risk factors were identified using multivariate logistic regression. The association between postoperative molecular-targeted therapy and stoma-free survival was further analyzed in patients with severe anal ulc

SUBMITTER: Nakao E 

PROVIDER: S-EPMC12766390 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature