Methylation Landscapes of Cartilage in Hip Osteoarthritis.

ABSTRACT:

Objective

To elucidate different methylation landscapes between cartilage of femoral neck fracture and preserved and damaged cartilages in hip osteoarthritis (OA).

Methods

Genome-wide DNA methylation data were acquired from two data sets in GEO database (GSE63106 and GSE63695), which were based on Illumina HumanMethylation450 BeadChip arrays. A total of 63 hip samples were selected for further analysis, including 19 cartilages obtained from patients with femoral neck fracture, 14 preserved cartilages, and 30 damaged cartilages obtained from patients with OA. We identified the differential methylated positions (DMPs) and genes between different cartilage groups.

Results

There were 116,750 DMPs and 51,200 DMPs identified in preserved and damaged cartilages compared to c

SUBMITTER: Jiang R 

PROVIDER: S-EPMC12766398 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature