Moving from a pilot study to large pragmatic trial in primary care settings: A study on acute rhinosinusitis.

ABSTRACT:

Background

Acute rhinosinusitis is one of the most common conditions seen in primary care. One in seven adults are diagnosed with ARS annually, resulting in one in five of all antibiotic prescriptions. Yet there has been limited research comparing the effectiveness of widely used treatments such as antibiotics and nasal steroids. Conducting such a trial in the context of decades of established practice poses unique challenges.

Methods

A feasibility phase was conducted with continuing feedback to provide refinement and guidance regarding the design of a large-scale, pragmatic randomized controlled trial. The pilot trial assessed the ability to enroll, retain, and evaluate adherence to the intervention and assessment protocols.

Results

The feasibility phase allowed us t

SUBMITTER: Merenstein D 

PROVIDER: S-EPMC12766510 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature