Polychlorinated biphenyl 153 alters the intestinal epithelial cell transcriptome.

ABSTRACT: Polychlorinated biphenyl 153 (PCB153) is one of the most persistent environmental pollutants and abundant PCB congeners detected in human tissues, primarily acquired through dietary exposure. The intestinal epithelium therefore represents a critical initial target for PCB-related toxicity. However, the molecular mechanisms by which PCB153 disrupts normal intestinal epithelial function remain incompletely understood. The present study investigated the effects of PCB153 exposure on non-transformed human intestinal epithelial cells (IECs) using transcriptomic profiling. The data revealed that PCB153 induced dose-dependent alterations in the IEC transcriptome. Key pathways affected by PCB153 included Wnt signaling, ABC transporters, cGMP-PKG signaling and metallothionein-mediated metal homeost

SUBMITTER: Ham H 

PROVIDER: S-EPMC12766560 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature