Novel cardiovascular magnetic resonance strain heterogeneity phenotypes predict cardiovascular events: A prospective UK Biobank study.

ABSTRACT:

Background

Global longitudinal (GLS), circumferential (GCS) and radial (GRS) strains may be insufficiently sensitive to early regional pathological cardiac remodeling on cardiovascular magnetic resonance imaging (CMR). Corresponding strain coefficients of variation, CoV_LS, CoV_CS and CoV_RS, may facilitate improved prognostication by quantifying contractile heterogeneity.

Objectives

To compare CoV_LS, CoV_CS, CoV_RS, to GLS, GCS, GRS, to predict incident cardiovascular (CV) events at population level, respectively.

Methods

CMR feature tracking-derived strain biomarkers from 60,746 UK Biobank participants were calculated. Kaplan-Meier survival analysis and Cox proportional hazards regression analyzed unadjust

SUBMITTER: Hesse K 

PROVIDER: S-EPMC12766616 | biostudies-literature | 2025 Winter

REPOSITORIES: biostudies-literature