Salvage Stereotactic Body Radiation Therapy for Locally Recurrent Prostate Cancer: Quality-of-Life Outcomes From a Prospective Clinical Trial.

ABSTRACT:

Purpose

Salvage stereotactic body radiation therapy (SBRT) for intraprostatic recurrence of prostate cancer is under study in early-phase clinical trials. Presently, the impact of this treatment on toxicity and health-related quality of life (HRQOL) is poorly defined. To our knowledge, we present the first report in the literature of HRQOL and psychometric outcomes from a mature, prospective clinical trial.

Methods and materials

NCT03253744 was a phase 1 trial of focal salvage SBRT to doses of 40.0 to 42.5 Gy with target volume delineation guided by ¹⁸F-DCFPyL positron emission tomography/computed tomography and magnetic resonance imaging. Secondary endpoints included longitudinal assessment of National Cancer Institute Common Terminology Criteria for Adverse Even

SUBMITTER: Patel KR 

PROVIDER: S-EPMC12766626 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature