The association between human papillomavirus type 16 seropositivity and oropharyngeal cancer among men living with HIV.

ABSTRACT:

Background

There are no methods for the early detection of human papillomavirus-driven oropharyngeal squamous cell carcinoma (HPV+OPSCC); however, HPV16 E6 seropositivity has been identified as a promising screening marker. Although people living with HIV have a higher risk of developing HPV+OPSCC, few studies have evaluated the association between HPV16 antibodies and HPV+OPSCC.

Methods

The association between HPV16 seropositivity (L1, E1, E2, E4, E6, and E7) and OPSCC was assessed among 2331 men living with HIV (MLWH) aged ≥40 years who had blood specimens banked within the Tennessee Center for AIDS Research biorepository between 2001 and 2019; some samples were collected before OPSCC diagnosis, and others after. The association between HPV16 seropositivity and OPSCC was a

SUBMITTER: Duff AJ 

PROVIDER: S-EPMC12766693 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature