Disentangling the inverse relationship between cancer and Alzheimer's or Parkinson's disease: A systematic review on Mendelian randomization studies.

ABSTRACT:

Introduction

Although studies have reported an inverse relationship between cancer and neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD), findings remain inconsistent. Observational studies are limited by survival bias and reverse causation. To better understand the relationship, we conducted a systematic review of Mendelian randomization (MR) studies examining both directions-assessing cancer as a risk factor for AD or PD, as well as AD or PD as exposures influencing cancer risk.

Methods

We systematically reviewed MR studies investigating the causal relation between cancer and either AD or PD. Cancer could be specified as either an exposure or an outcome of interest. Articles published until August 2024 were identified, screened, and a

SUBMITTER: Aung KZ 

PROVIDER: S-EPMC12766696 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature