Changes in the levels and predictors of per- and poly-fluoroalkyl substances in maternal plasma, relative to timelines of EPA PFOA Stewardship.

ABSTRACT:

Background

Declines of several common-studied PFAS noted in the U.S. likely reflect policies that successfully reduced long-chained PFAS production and emission such as the EPA PFOA Stewardship Program. Policy impacts on under-studied PFAS and on predictors of PFAS exposure remain unknown.

Objective

To assess changes in population-levels and exposure predictors of 10 PFAS in the Boston Birth Cohort (BBC) by Stewardship timelines.

Materials and methods

In 1,288 BBC mothers who delivered 1999-2016, the current study focused on 10 PFAS in plasma samples collected 24-72 h postpartum. We estimated PFAS percent differences (%Δ), stratified by the Stewardship timelines. We evaluated predictors related to sources, vulnerability, blood-loss, and diet during pregnancy.

Resul

SUBMITTER: Choi G 

PROVIDER: S-EPMC12766716 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature