Concordance between presenting features and relapse in granulomatosis with polyangiitis: implications for risk assessment and counselling.

ABSTRACT:

Objective

To investigate the concordance between organ involvement at diagnosis and relapse in granulomatosis with polyangiitis and factors associated with new disease features at relapse.

Methods

Data from a national database of newly diagnosed patients was analysed. Clinical features were recorded at diagnosis and relapse, grouped by organ system. ORs and HRs were used to assess associations between baseline features and first relapse. Factors independently associated with new organ involvement at relapse were identified using multivariable logistic regression.

Results

Among 795 patients (median follow-up 3.5 years), 394 (50%) relapsed; organ involvement at relapse was available for 376 patients. Relapses most often affected ear, nose and throat (ENT), lungs and kid

SUBMITTER: Iudici M 

PROVIDER: S-EPMC12766798 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature