Overcoming impaired antigen presentation in tumor-draining lymph nodes facilitates immunotherapy.

ABSTRACT:

Background

Immunotherapies have revolutionized cancer care in recent decades, but approved therapies often fail and currently only target specific steps in the generation of anti-cancer immune responses. Notably, the majority of approved immunotherapies do not target antigen processing and presentation, which are key steps in the development of immune responses and harbor potential as targets to improve immunotherapy. Here, we hypothesize that tumor-mediated alterations in cytokine concentrations alter antigen presentation, which can be normalized by locoregional cytokine delivery or targeted immunological adjuvant delivery.

Methods

We used mouse models of breast cancer, with analysis by flow cytometry, immunofluorescence, confocal imaging, and single-cell RNA sequencing to

SUBMITTER: O'Melia MJ 

PROVIDER: S-EPMC12766806 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature