Efficacy of Fetal Ear Length as a Prenatal Marker of Chromosomal Anomalies: A Prospective, Multicenter Cohort Study in a Southern European Population.

ABSTRACT:

Objective

To develop a nomogram of fetal ear length (FEL) by gestational age in a healthy pregnant Southern European population and assess its potential as a prenatal ultrasound marker of chromosomal anomalies in this demographic.

Methods

This prospective, multicenter cohort study included low-risk pregnancies from 11 + 2 to 34 + 6 gestational age. A nomogram was constructed based on gestational age for healthy fetuses with normal perinatal outcomes. Intraobserver and interobserver reliability were evaluated. To assess the efficacy of FEL as a marker of chromosomal anomalies, a multivariate logistic regression analysis was performed; sensitivity and specificity were calculated.

Results

A total of 1923 FEL measurements were obtained from 1331 singleton pregnancies. Usi

SUBMITTER: Baldrich E 

PROVIDER: S-EPMC12766865 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature