Elevated CHI3L1 as a Potential Biomarker of Cognitive Dysfunction in Anti-NMDAR Encephalitis: Evidence From Clinical Results and Mice Model.

ABSTRACT:

Background

Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is frequently associated with long-term cognitive impairment. However, the underlying mechanisms remain poorly understood, and reliable biomarkers for predicting cognitive outcomes are lacking.

Methods

We established an active immunization mouse model of anti-NMDAR encephalitis by immunizing with the GluN1_356-385 peptide. Hippocampal proteomic profiling was performed, followed by molecular and histological validation. Behavioral tests were used to assess cognitive function. In parallel, serum and cerebrospinal fluid (CSF) samples were analyzed from a clinical cohort of children with anti-NMDAR encephalitis to evaluate expression of the targeted biomarker and its association with clinical outcomes.<

SUBMITTER: Li Y 

PROVIDER: S-EPMC12766899 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature