Differences in the Efficacy of Cognitive Function Treatment Related to Functional Patterns in the Frontal-Limbic Network in Patients With Bipolar Disorder.

ABSTRACT:

Background

This study aimed to identify neurobiomarkers that predict the efficacy of treatment of cognition in patients with bipolar disorder (BD).

Methods

Regional homogeneity (ReHo) and degree centrality (DC) values, which are two functional magnetic resonance imaging indicators, were analyzed to compare differences in brain activities between patients with BD and healthy controls (HC).

Results

BD patients (N = 92) exhibited increased activity in the right hippocampus or right parahippocampal gyrus compared to HC, while their ReHo and DC values in the left middle frontal gyrus decreased in the resting state. The delayed memory scores were predicted by using connectome-based predictive modeling in patients with BD at baseline. After 12 weeks of treatment, the patient

SUBMITTER: Li S 

PROVIDER: S-EPMC12766901 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature