<i>Alpl</i> ablation in dental epithelium disrupts ameloblasts and incisor enamel mineralization in male mice.

ABSTRACT: Tissue-nonspecific alkaline phosphatase (gene: ALPL; protein: TNAP) is a mineralization-associated enzyme that catalyzes several physiological substrates and is widely expressed in skeletal and nonskeletal tissues indicating diverse physiological actions. Loss-of-function mutations in ALPL cause hypophosphatasia (HPP), an inherited skeletal dysplasia featuring rickets and osteomalacia. Hypophosphatasia is also associated with dentoalveolar abnormalities, including dentin defects and acellular cementum hypoplasia, resulting in premature tooth loss. Some reports indicate HPP causes enamel defects. We conditionally ablated Alpl in enamel organ by crossing Krt14^Cre and Alpl^fl/fl mice to generate Krt14^Cre ;Alpl^fl

SUBMITTER: Mohamed FF 

PROVIDER: S-EPMC12766919 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature