Tumor-infiltrating neutrophil is an independent prognostic factor in pancreatic ductal adenocarcinoma.

ABSTRACT:

Background

Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies. Tumor-infiltrating neutrophils (TINs) have been implicated in tumor progression and poor prognosis; however, their roles in PDAC remain unclear. TINs have been shown to granulocytic myeloid-derived suppressor cells (G-MDSCs) which inhibit adaptive immune responses and share morphological and functional features with classical neutrophils. G-MDSCs, unlike classical neutrophils, express myeloperoxidase (MPO). We evaluated the significance of TINs and MPO expression as a marker for prognosis in the PDAC.

Methods

We retrospectively analyzed 128 patients with surgically resected PDAC. The presence of TIN was assessed on hematoxylin and eosin-stained slides and immunohistochemistry was

SUBMITTER: Son SM 

PROVIDER: S-EPMC12766948 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature