Molecular insights into the antimicrobial and cardiometabolic functions of Lactobacillus crispatus isolated from the reproductive tract microbiota of Indian women.

ABSTRACT:

Background

Lactobacillus crispatus is a dominant member of the healthy female reproductive tract microbiota, contributing to mucosal homeostasis and pathogen exclusion. Numerous studies have highlighted the protective effects of L. crispatus against both intestinal and genital infections. In the present study, we build on this foundation to investigate the broader health-promoting properties of L. crispatus, focusing on its antimicrobial and metabolic functions; and its protective roles in hepatic and cardiometabolic disorders.

Methods

Three L. crispatus strains were selected from a panel of sixty isolates based on comprehensive genome mining analyses described in our previous publication. In the present study, we generated complete genome data for these three strains, and d

SUBMITTER: Mahajan S 

PROVIDER: S-EPMC12766959 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature