Polydopamine-encapsulated modified Pulsatilla decoction: a strategy to enhance ulcerative colitis therapy.

ABSTRACT:

Background

In Traditional Chinese Medicine (TCM), ulcerative colitis (UC) is often categorized as "protracted dysentery." Pulsatilla Decoction has been reported to exert therapeutic benefits in patients with protracted dysentery. To potentially improve therapeutic outcomes in ulcerative colitis, we prepared a modified Pulsatilla Decoction (MPD). Preliminary clinical observations have suggested that MPD may alleviate symptoms in UC patients. However, rectal enema of MPD is often limited by suboptimal patient compliance and relatively short colonic retention. These limitations underscore the need for new TCM formulations. In this study, we encapsulated MPD within polydopamine (PDA) nanoparticles to prolong colonic residence and evaluate therapeutic effects in a UC model.

Methods</

SUBMITTER: Chen YJ 

PROVIDER: S-EPMC12766960 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature