Astragaloside IV ameliorates atrazine-induced male reproductive toxicity: an <i>in vivo</i> and <i>in silico</i> analysis.

ABSTRACT:

Introduction

Atrazine (ATZ) stands as the most widely utilized herbicide globally and is known for its adverse impacts on the reproductive system. Although astragaloside IV (AS IV) is well known for possessing various health benefits, its protective effects against ATZ-induced toxicity remain unexplored. This study aimed to investigate the ameliorative potential of AS IV against ATZ-induced male reproductive toxicity in mice.

Methods

Eight-week-old CD-1 mice were allocated into four groups (n = 10). ATZ and AS IV were administered at doses of 100 mg/kg/day and 40 mg/kg/day, respectively. Treatments were continued for 21 days, after which the animals were sacrificed for plasma biochemical analyses and testes collection for histopathological examination. One-way analysis of va

SUBMITTER: Sirasanagandla SR 

PROVIDER: S-EPMC12766972 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature