Associations of alcohol consumption with expression of CD44, CD24, and ALDH1A1 stem cell markers in benign breast biopsy samples.

ABSTRACT:

Purpose

We investigated the associations of alcohol consumption with CD44, CD24, and ALDH1A1 stem cell markers' expression in non-cancerous breast tissue.

Methods

We included 312 cancer-free women with biopsy-confirmed benign breast disease (BBD) from the Nurses' Health Study (NHS) and NHS II cohorts. Immunohistochemistry (IHC) was performed on tissue microarrays (TMAs) that were created from histologically normal breast tissue. For each core, the IHC expression was assessed using semi-automated software and expressed as % of positively stained cells for each marker out of the total cell count. All expression measures were log-transformed. Alcohol consumption data was obtained from semi-quantitative food frequency questionnaires. Information on other covariates was collected

SUBMITTER: Ratcliffe M 

PROVIDER: S-EPMC12766974 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature