Reinstating Niche Failure in Diabetic Cranial Defects via Chronotaxic Signal-Amplifying Fluidic Biomimetic Hydrogel.

ABSTRACT: Cranial stem cell niches (SCNs) are intrinsically scarce and hypoactive, and, exacerbated by chronic inflammation in diabetes, lead to niche failure and regenerative deficit after injury. Herein, an in situ moldable fluidic biomimetic niche (GelSSO/PDA@SDF) is developed as a chronotaxic signal amplifier to enhance SCN abundance and activity, aiming to restore autonomous regeneration. This biomimetic niche integrates PDA@SDF nanoparticles and a GelSSO hydrogel precursor, synthesized via dopamine self-polymerization/protein coupling and sequential methacrylation/sequence-specific oligodeoxynucleotide (SSO) grafting, respectively. Photocrosslinked GelSSO/PDA@SDF can preferentially and sustainably release PDA@SDF nanoparticles to trigger early-phase signal amplification, characterized by SDF-1

SUBMITTER: Mao Y 

PROVIDER: S-EPMC12766998 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature