Neuroprotection and Axonal Regeneration via ECM-Mimetic Nanofibers Incorporating Metal-Phenolic Network Nanoparticles Toward Spinal Cord Injury Repair.

ABSTRACT: Spinal cord injury (SCI) triggers secondary pathological cascades, such as excitotoxicity, neuroinflammation, and glial scarring, creating a hostile injury microenvironment that exacerbates the death of spared neurons and inhibits axonal regeneration, thus impeding functional recovery. While aligned electrospun nanofibers (NFs) fabricated from decellularized extracellular matrix (dECM) can mimic topological and bioactive cues of native ECM to guide axonal regrowth, they fail to intervene in these secondary pathological cascades. To address this limitation, Mg²⁺ and epigallocatechin gallate (EGCG) molecules are initially self-assembled into nanoparticles (MPN NPs) via metal-phenolic coordination, and then integrated with dECM by electrospinning to form an aligned fibrous scaffold

SUBMITTER: Chen S 

PROVIDER: S-EPMC12767005 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature