Advancing Insights Into Visceral Leishmaniasis: Challenges, Innovations, and Future Directions in Global Disease Management.

ABSTRACT:

Background

Visceral leishmaniasis (VL), also known as kala-azar, is a life-threatening neglected tropical disease primarily caused by Leishmania donovani and transmitted by infected sandflies. Despite notable advancements in public health, VL continues to pose significant challenges, especially in South Asia, East Africa, and South America.

Methods

A systematic review was conducted in accordance with PRISMA guidelines. Peer-reviewed literature published from 2000 to 2024 was retrieved from PubMed, Scopus, and Web of Science to assess epidemiological patterns, diagnostic advancements, therapeutic options, and vector control strategies.

Results

The analysis revealed progress in diagnostic tools such as rK39-based rapid tests and molecular diagnostics. Therapeutic

SUBMITTER: Abbasi E 

PROVIDER: S-EPMC12767020 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature