Serum Albumin and Glycemic Variability Could Contribute to Diabetic Retinopathy Progression by Regulating Chronic Inflammatory Pathways.

ABSTRACT:

Purpose

Despite managing glycemic levels and other risk factors, individuals with type 2 diabetes (T2DM) may still experience diabetic retinopathy (DR) progression. This study investigated clinical predictors of DR progression in T2DM patients following bariatric surgery.

Methods

This study was a retrospective post hoc analysis of participants from a clinical randomized controlled trial of bariatric surgery patients with T2DM (ACTRN12611000751976) who had complete DR screening and blood data at baseline and 5 years post-bariatric surgery. Plasma cytokine concentrations were also examined.

Results

DR progression was strongly associated with a postoperative decrease in serum albumin (OR = 0.461, 95% CI: 0.221-0.962, p = 0.039). This decrease also predicted postop

SUBMITTER: Maran JJ 

PROVIDER: S-EPMC12767037 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature