Targeted Expansion of Treg Cells to Induce Immune Tolerance after Kidney Transplantation.

ABSTRACT: Kidney transplantation remains the optimal treatment for end-stage renal disease, yet faces persistent challenges including organ shortages and risk of infection due to systemic immunosuppression. Cell therapy is expected to replace immunosuppressive agents. However, while Treg cell therapy can mitigate immune rejection, it fails to significantly prolong graft survival because peripherally induced Treg cells exhibit transdifferentiation potential in the circulatory system. Recent advances in nanocarrier systems offer promising approaches for achieving graft-specific immune tolerance. Through single-cell sequencing analysis, CD248 is identified as a pivotal stromal cell marker in renal allograft rejection, modulated by HIF-1α and IL-1β signaling pathways. Leveraging macrophage membrane coat

SUBMITTER: Lu T 

PROVIDER: S-EPMC12767053 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature