Ultrafine Molybdenum Wire Braided Neurointerventional Implants: Bridging Biodegradability and Neurovascular Safety for Stroke Treatment.

ABSTRACT: Neurovascular implants for stroke intervention face a critical dilemma: permanent devices (e.g., nitinol stents, platinum coils) often trigger chronic inflammation and recurrence, whereas biodegradable alternatives (Mg, Fe, Zn alloys) lack radiopacity or raise neurotoxicity concerns. Here, we introduce φ50 µm molybdenum (Mo) wire braided implants that integrate procedural efficacy with biological safety. Mo demonstrates negligible hemolysis (<5%), platelet-inert surfaces, and preserved coagulation kinetics, together with robust cytocompatibility across neurovascular unit cells (endothelia, astrocytes, neurons) under both physiological and ischemia-reperfusion conditions. In vivo, Mo stent wires implanted in rodent carotids maintained blood homeostasis, organ integrity, and neurological fun

SUBMITTER: Shen Y 

PROVIDER: S-EPMC12767060 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature