Nanoparticle-Modified Nanofibers Induce Ferroptosis and Stimulate Antitumor Immunity for Melanoma Therapy.

ABSTRACT: Melanoma, a highly aggressive and therapy-resistant cutaneous malignancy, presents formidable clinical challenges owing to its propensity for early metastasis and frequent postoperative recurrence. Here, a nanofiber-based drug delivery system (5F/STFM/R-ES) is developed that synergistically induces ferroptosis and potentiates immunotherapy to inhibit melanoma growth and reduce the risk of metastasis and recurrence. To this end, mesoporous silica nanoparticles encapsulating resiquimod (R848) are surface-coated with Fe/Mn-based metal-polyphenol networks (TFM) to form STFM/R. Subsequently, STFM/R is electrospun into 5-fluorouracil-loaded nanofibers. When applied to the tumor site, 5-fluorouracil and STFM/R are released. Following the degradation of STFM/R, the release of Fe²⁺ trigg

SUBMITTER: Li M 

PROVIDER: S-EPMC12767067 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature