ARL5B Drives Esophageal Squamous Cell Carcinoma Progression via ROCK1-SREBP1-Mediated Lipid Metabolic Reprogramming.

ABSTRACT: Esophageal squamous cell carcinoma (ESCC) remains a highly aggressive malignancy with a 5 year survival rate below 30%, underscoring the urgent need for targeted therapeutic approaches. Here adenosine diphosphate (ADP)-ribosylation factor-like protein 5B (ARL5B) is identified as a key candidate oncogene that drives ESCC progression by modulating lipid metabolism via the ras homologous-associated coiled-coil containing protein kinase 1(ROCK1)-sterol regulatory element-binding protein 1 (SREBP1) signaling axis. Through the Cancer Genome Atlas (TCGA) pan-cancer analysis, ARL5B is initially identified as a promising candidate gene, correlating with advanced tumor, node, metastasis (TNM) stages and poor survival. Functional assays demonstrate that ARL5B knockdown significantly suppresses cell p

SUBMITTER: Ma X 

PROVIDER: S-EPMC12767069 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature