New Clues to the Pathogenesis of Idiopathic Orbital Inflammation: Elevated IL-8 and MCP-1 in Tear Fluid.

ABSTRACT:

Objectives

To characterize tear cytokine profiles in patients with idiopathic orbital inflammation (IOI) and analyze the expression of altered cytokines in blood and involved tissues.

Methods

This case-control study enrolled 18 IOI patients and 11 age-/sex-matched controls. Ocular Surface Disease Index (OSDI), corneal fluorescent staining, tear film breakup time (TBUT), Schirmer I test, and other clinical and laboratory parameters were obtained from all participants. Concentrations of cytokines in tear fluid, blood, and tissues were determined using a multiplex bead immunoassay system, enzyme-linked immunosorbent assay, and immunohistochemistry.

Results

Significantly elevated levels of interleukin (IL)-8 and monocyte chemoattractant protein (MCP)-1 (both p < 0.

SUBMITTER: Chen J 

PROVIDER: S-EPMC12767073 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature