Self-Assembled Dictamni Cortex Nanoparticles Ameliorate Psoriasis by Epigenetic Modulation of HSP90AB1 and Suppression of the Inflammatory Response.

ABSTRACT: Psoriasis, a chronic immune-mediated dermatological disease with high recurrence rates and limited therapeutic efficacy, requires novel treatment strategies. Dictamni Cortex (BXP), a traditional Chinese medicine (TCM), has demonstrated potential in alleviating psoriasis; however, its clinical application is hampered by poor water solubility and low bioavailability. It is developed infinite coordination polymer nanoparticles (BXP-Fe (III) ICPs, NB), which enhance the aqueous solubility by 95-fold and bioavailability of BXP, exerting therapeutic effect through efficient transdermal delivery. NB significantly suppresses keratinocyte hyperproliferation, inflammation, and oxidative stress in both M5 (a cocktail of cytokines)-treated human epidermal keratinocytes (HEKa) cells and imiquimod (IMQ)

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC12767101 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature