EM2, a Natural Product MST1/2 Kinase Activator, Suppresses Non-Small Cell Lung Cancer via Hippo Pathway Activation.

ABSTRACT: Lung cancer, 85% of which is non-small cell lung cancer (NSCLC), is the cancer with the highest incidence and mortality rate worldwide. Despite recent advancements in therapeutic approaches, the efficacy of conventional radiotherapy and chemotherapy remains suboptimal, highlighting the urgent need for more effective treatment strategies. Dysregulation of kinases MST1 and MST2 (MST1/2) is implicated in the progression of NSCLC, positioning MST1/2 as a potential therapeutic target. However, no high-selectivity and high-efficacy MST1/2 activator is identified to date. In this study, by using computer-aided virtual screening combined with cell experiments, EM2 is identified as a promising MST1/2-binding candidate. Subsequent experimental validation demonstrates that EM2 significantly suppresse

SUBMITTER: Yang S 

PROVIDER: S-EPMC12767113 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature