Cumulative estimated glucose disposal rate predicts frailty progression in Chinese adults with diabetes: a 9-year follow-up cohort study.

ABSTRACT:

Introduction

Frailty is a common adverse outcome in diabetes that is linked to reduced quality of life and increased mortality and is strongly associated with insulin resistance. However, the relationship between long-term cumulative insulin resistance and frailty progression remains unclear, particularly in Chinese adults with diabetes.

Methods

We used data from the China Health and Retirement Longitudinal Study. We included 451 participants aged 45 years or older with baseline diabetes in 2011 who had frailty index scores based on 26 health deficit items across four waves (2011, 2015, 2018, 2020) and complete data in 2011 and 2015 to calculate cumulative estimated glucose disposal rate, cumulative triglyceride-glucose index, and cumulative triglyceride-glucose-body mass in

SUBMITTER: Zhao B 

PROVIDER: S-EPMC12767217 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature