Single-Cell Transcriptomics Reveal Microenvironment Alterations in Canine Peri-Implantitis.

ABSTRACT:

Background

Peri-implantitis, a major contributor to dental implant failure, lacks comprehensive insights into tissue-specific heterogeneity as current researches predominantly focus on the whole peri-implant tissue rather than distinct molecular and cellular dynamics in gingiva and alveolar bone microenvironments. Furthermore, ethical challenges hinder the acquisition of healthy peri-implant tissues, limiting our understanding of peri-implantitis progression and the development of targeted therapies.

Methods

We established a controlled peri-implantitis model in beagle dogs, enabling ethical collection of healthy control tissues. Single-cell RNA sequencing (scRNA-seq) transcriptomics profiling was conducted on gingiva and alveolar bone tissues from diseased and healthy contro

SUBMITTER: Wang M 

PROVIDER: S-EPMC12767392 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature