Foxj2 Attenuates LPS-Induced Inflammatory Response in Macrophages.

ABSTRACT:

Background

Macrophages are central to innate immune responses and are crucial in maintaining homeostasis and managing inflammatory diseases. Forkhead box J2 (Foxj2) is a member of the forkhead/hepatocyte nuclear factor 3 transcription factor family and is essential for multiple biological functions. However, the involvement of Foxj2 in the inflammatory process in macrophages remains unclear.

Objective

The present study aimed to explore the role of Foxj2 in the inflammatory processes of macrophages activated through lipopolysaccharide (LPS) stimulation.

Methods

The modulation of Foxj2 expression in macrophages in response to LPS stimulation was investigated via reverse-transcription quantitative (RT-q) PCR, Western blot, and immunofluorescence staining assays. Macropha

SUBMITTER: Huang P 

PROVIDER: S-EPMC12767408 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature