Enhanced Primary Motor Cortex Astrocyte Calcium Signaling With Motor Learning.

ABSTRACT: Astrocytes form an integral part of the nervous system and are proposed to modulate neuronal circuits and behavior. The motor cortex plays a key role in the planning and execution of voluntary movements and makes key contributions to motor skill learning. However, whether motor skill learning modulates astrocytic Ca²⁺ signaling in the primary motor cortex (M1) is not known. To understand the role of astrocytes in the M1, we first characterized the Ca²⁺ signaling properties in astrocyte subcompartments in awake mice. We found that the subcompartments exhibited different Ca²⁺ event properties during the no movement periods and locomotion. We then asked whether astrocytic Ca²⁺ signaling in M1 is modulated with the acquisition of a skilled forelimb r

SUBMITTER: Padmashri R 

PROVIDER: S-EPMC12767412 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature