Immunomodulatory Mechanisms of Rehmanniae Radix Praeparata-Achyranthes Root-Chinese Angelica Root Combination in Nontraumatic Osteonecrosis of the Femoral Head: A Comprehensive Network Pharmacology and Molecular Docking Study Focusing on Immunological Pathways.

ABSTRACT:

Objective

Nontraumatic osteonecrosis of the femoral head (NONFH) is a devastating condition characterised by immune dysregulation and sterile inflammation, which are increasingly acknowledged as central pathogenic mechanisms. This study aims to identify the core herbal combination for NONFH and systematically explore its immunomodulatory effects and underlying pharmacological mechanisms, with a focus on immune system interactions.

Methods

The core combination 'Rehmanniae radix praeparata (SDH)-achyranthes root (NX)-Chinese angelica root (DG)' (SND) was identified via data mining of clinical literature using the Traditional Chinese Medicine Inheritance Support System (TCMISS) V2.5 platform. Its chemical constituents were characterised by ultrahigh performance liquid chromatog

SUBMITTER: Li X 

PROVIDER: S-EPMC12767418 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature