Ferulic Acid Alleviates Inflammation and Promotes Osteogenic Differentiation in Periodontitis by Inhibiting NF-<i>κ</i>B Pathway.

ABSTRACT:

Background

Periodontitis refers to a chronic inflammatory illness that induces the destruction of periodontal tissues and can be driven by bacterial lipopolysaccharide (LPS) of pathogens. This study investigated the anti-inflammatory potential and underlying mechanisms of ferulic acid (FA) in periodontitis.

Method

An in vitro periodontitis model was established by treating human periodontal ligament stem cells (hPDLSCs) with 10 µg/mL LPS for 24 h. The experimental groups included a control group, an LPS-treated group, and an LPS + FA cotreatment group. In addition, phorbol 12-myristate 13-acetate (PMA) treatment was used for nuclear factor κB (NF-κB) pathway activation. Cell proliferation was evaluated using the Cell Counting Kit-8 (CCK-8) test, and osteogenic

SUBMITTER: Wang Q 

PROVIDER: S-EPMC12767440 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature