Circulating Extracellular Vesicles in the Pathogenesis of Heart Failure in Patients With Chronic Kidney Disease.

ABSTRACT:

Background

Cardiovascular disease causes >50% of deaths in patients with advanced chronic kidney disease (CKD). Clinical studies suggest that kidney-derived factors contribute to cardiovascular disease development in CKD, independently of comorbidities. However, to date, no kidney-specific humoral risk factor that triggers direct cardiotoxicity has been identified. In this cross-sectional study, we investigate how, in patients with CKD, circulating extracellular vesicles (EVs) facilitate pathological kidney-heart communication, thereby causing cardiotoxicity, impairing cardiac function, and contributing to heart failure progression.

Methods

We investigated the function of EVs from patients with CKD and adenine diet-induced CKD mice on cardiomyocyte and cardiac contractility.

SUBMITTER: Li X 

PROVIDER: S-EPMC12767446 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature