Diverse infections transcriptionally reprogram the intestinal epithelium and epithelial-immune cell interactions.

ABSTRACT: The distal small intestine plays vital roles in host physiology by regulating nutrient and fluid homeostasis. Despite being impacted in Crohn's disease and a major target for a range of infections, we know relatively little about the complexity of cellular responses and cell-cell communication in the ileum during infection. Single cell and spatial transcriptomics have emerged as powerful technologies to study tissue heterogeneity in the gut, but these tools have focused on the large intestine, in part due to the accessibility of this tissue for biopsies and its importance in cancer. Here we present GutPath, an atlas of over 500,000 single cells with RNA and protein expression profiles for 91 cell states in the ileum across diverse infectious archetypes. We show that GutPath accurately capt

SUBMITTER: Hart A 

PROVIDER: S-EPMC12767538 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature