Merging Lignin and Glycerol Carbonate Valorization Toward the Green Synthesis of β-Adrenergic Blocker Esmolol.

ABSTRACT: Producing nitrogen-containing chemicals through the direct combination of by-products readily available from agricultural waste, including renewable aromatic building blocks from lignin, is a highly attractive approach for sustainable biorefining processes. Here, we describe a novel synthetic/catalytic route toward the production of the highly valuable β-adrenergic blocker esmolol. Our strategy consists of: 1) Reductive Catalytic Fractionation (RCF) of sugarcane lignocellulose mediated by copper porous metal oxides (Cu₂₀PMO) in MeOH, leading to the in situ formation of methyl 3-(4-hydroxyphenyl) propionate (1H) with good selectivity (>70%), followed by 2) the selective catalytic amination of glycerol carbonate (GlyC) with isopropyl amine via the borrowing hydrogen strategy, and

SUBMITTER: Castillo-Garcia AA 

PROVIDER: S-EPMC12767559 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature